The role of vitamin D deficiency on migraine chronicity has not been clearly identified. The pathogenic mechanism of migraine chronicity presumes to be associated with a neurotransmitter imbalance and upregulation of inflammatory pathways in CNS resulting in central amplification of peripheral pain signals. [ 9] Overall, there is not enough evidence to recommend vitamin D supplementation to all headache patients, but the current literature indicates that it may be beneficial in some patients suffering headaches, mainly migraineurs, to reduce the frequency of headaches, especially in those with vitamin D deficiency. Vitamin D deficiency is associated with chronic pain disorder, depression, and several neurological disorders. 1, 2, 3, 4, 5, 6 The brain has an abundance of vitamin D receptors and there is evidence of a nonskeletal role of vitamin D in inflammation, immunity, and the metabolism of neurotransmitters. 6, 7, 8 In addition, vitamin D has been asso atLtMIP. Summary. Scientists suggest there are links between deficiencies vitamin D, riboflavin, magnesium and migraine. They also indicate that supplementing these nutrients may ease symptoms. For

vitamin d deficiency and migraines